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Police were called to Fitzroy Street following a report of an alleged assault about 3am.

While a man was being arrested, several people intervened.

During the course of the arrest, OC spray was deployed and two police officers were injured.

A 26-year-old St Kilda man, a 27-year-old Langwarrin man, a 25-year-old Langwarrin woman and a 38-year-old Frankston man were arrested yesterday.

They have all been charged with two counts of assault police, affray, violent disorder, intentionally cause injury and other assault related offences.

They will appear at the Melbourne Magistrates’ Court this morning.

The investigation remains ongoing and police are continuing to review CCTV footage.

Anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report at www.crimestoppersvic.com.au.